Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1205891..1206368 Replicon chromosome
Accession NZ_CP047804
Organism Staphylococcus aureus strain UP_774

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S60_RS06095 Protein ID WP_000052076.1
Coordinates 1206180..1206368 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S60_RS06090 Protein ID WP_001059690.1
Coordinates 1205891..1206151 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S60_RS06055 1201284..1202000 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S60_RS06060 1202148..1202570 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S60_RS06065 1202969..1203463 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S60_RS06070 1203618..1204235 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S60_RS06075 1204308..1204889 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S60_RS06080 1205114..1205350 + 237 WP_000349581.1 hypothetical protein -
E3S60_RS06085 1205347..1205550 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S60_RS06090 1205891..1206151 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S60_RS06095 1206180..1206368 + 189 WP_000052076.1 hypothetical protein Toxin
E3S60_RS06100 1206556..1207125 + 570 WP_001106658.1 hypothetical protein -
E3S60_RS06105 1207213..1207497 + 285 WP_001004399.1 hypothetical protein -
E3S60_RS06110 1207559..1207777 + 219 WP_000005886.1 hypothetical protein -
E3S60_RS06115 1208269..1208469 - 201 WP_001059082.1 cold-shock protein -
E3S60_RS06120 1208826..1209512 - 687 WP_000141557.1 thermonuclease family protein -
E3S60_RS06125 1209853..1210374 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147972 WP_000052076.1 NZ_CP047804:1206180-1206368 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147972 NZ_CP063386:c5610190-5609912 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCTGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147972 WP_001059690.1 NZ_CP047804:1205891-1206151 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147972 NZ_CP063386:c5609900-5609595 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References