Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1179333..1179810 Replicon chromosome
Accession NZ_CP047803
Organism Staphylococcus aureus strain UP_1097

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S62_RS05980 Protein ID WP_000052076.1
Coordinates 1179622..1179810 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S62_RS05975 Protein ID WP_001059690.1
Coordinates 1179333..1179593 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S62_RS05940 1174728..1175444 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S62_RS05945 1175592..1176014 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S62_RS05950 1176413..1176907 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S62_RS05955 1177063..1177680 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S62_RS05960 1177751..1178332 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S62_RS05965 1178556..1178792 + 237 WP_000368687.1 hypothetical protein -
E3S62_RS05970 1178789..1178992 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S62_RS05975 1179333..1179593 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S62_RS05980 1179622..1179810 + 189 WP_000052076.1 hypothetical protein Toxin
E3S62_RS05985 1179998..1180567 + 570 WP_001106662.1 hypothetical protein -
E3S62_RS05990 1180655..1180927 + 273 WP_001004400.1 hypothetical protein -
E3S62_RS05995 1181000..1181218 + 219 WP_000005884.1 hypothetical protein -
E3S62_RS06000 1181715..1181915 - 201 WP_001059082.1 cold-shock protein -
E3S62_RS06005 1182272..1182958 - 687 WP_001622483.1 thermonuclease family protein -
E3S62_RS06010 1183299..1183820 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147960 WP_000052076.1 NZ_CP047803:1179622-1179810 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147960 NZ_CP063380:4638013-4638267 [Pectobacterium versatile]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCTG
GTTTCTGGTCGCGCCGCATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGGTGACGCCATGATGATAGCCGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147960 WP_001059690.1 NZ_CP047803:1179333-1179593 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147960 NZ_CP063380:4637765-4638016 [Pectobacterium versatile]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References