Detailed information of TA system TA147959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 159853..160629
• Replicon: chromosome
• Accession: NZ_CP047803
• Organism: Staphylococcus aureus strain UP_1097

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3S62_RS01070
• Protein ID: WP_160200271.1
• Coordinates: 160477..160629 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S62_RS01065
• Protein ID: WP_001251224.1
• Coordinates: 159853..160452 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S62_RS01045	155769..157226	+	1458	WP_000649917.1	ABC transporter permease subunit	-
E3S62_RS01050	157219..157941	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S62_RS01055	158092..159219	+	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S62_RS01060	159224..159694	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S62_RS01065	159853..160452	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S62_RS01070	160477..160629	+	153	WP_160200271.1	hypothetical protein	Toxin
E3S62_RS01075	161392..161787	+	396	WP_000901019.1	hypothetical protein	-
E3S62_RS01080	161983..163368	+	1386	WP_000116239.1	class II fumarate hydratase	-
E3S62_RS01085	163825..164646	-	822	WP_160199684.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	157213..227390	70177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6026.40 Da
• Isoelectric Point: 3.9075

>T147959 WP_160200271.1 NZ_CP047803:160477-160629 [Staphylococcus aureus]
MYKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T147959 NZ_CP063380:4637765-4638016 [Pectobacterium versatile]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147959 WP_001251224.1 NZ_CP047803:159853-160452 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147959 NZ_CP063380:4638013-4638267 [Pectobacterium versatile]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCTG
GTTTCTGGTCGCGCCGCATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGGTGACGCCATGATGATAGCCGCCTGC
CGCTACCACTATTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4