Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 89812..90600 | Replicon | chromosome |
| Accession | NZ_CP047803 | ||
| Organism | Staphylococcus aureus strain UP_1097 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | E3S62_RS00495 | Protein ID | WP_153157762.1 |
| Coordinates | 89812..90273 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | E3S62_RS00500 | Protein ID | WP_000333630.1 |
| Coordinates | 90286..90600 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S62_RS00470 | 84880..85080 | + | 201 | WP_000180459.1 | DUF1128 family protein | - |
| E3S62_RS00475 | 85092..86339 | + | 1248 | WP_000656302.1 | aminopeptidase | - |
| E3S62_RS00480 | 86429..86959 | + | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
| E3S62_RS00485 | 87222..88367 | - | 1146 | WP_033858404.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| E3S62_RS00490 | 88412..89458 | - | 1047 | WP_001145732.1 | site-specific integrase | - |
| E3S62_RS00495 | 89812..90273 | - | 462 | WP_153157762.1 | toxin | Toxin |
| E3S62_RS00500 | 90286..90600 | - | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| E3S62_RS00505 | 90752..90988 | + | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| E3S62_RS00510 | 91002..91145 | + | 144 | WP_001648348.1 | hypothetical protein | - |
| E3S62_RS00515 | 91135..91344 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| E3S62_RS00520 | 91784..91969 | + | 186 | WP_000933363.1 | helix-turn-helix domain-containing protein | - |
| E3S62_RS00525 | 91971..92723 | + | 753 | WP_031785300.1 | phage antirepressor KilAC domain-containing protein | - |
| E3S62_RS00530 | 92739..92882 | + | 144 | WP_000939499.1 | hypothetical protein | - |
| E3S62_RS00535 | 92892..93545 | - | 654 | WP_001803402.1 | hypothetical protein | - |
| E3S62_RS00540 | 93616..93837 | + | 222 | WP_000594791.1 | hypothetical protein | - |
| E3S62_RS00545 | 93830..93991 | + | 162 | WP_000066014.1 | DUF1270 domain-containing protein | - |
| E3S62_RS00550 | 94083..94343 | + | 261 | WP_000291075.1 | DUF1108 family protein | - |
| E3S62_RS00555 | 94356..94892 | + | 537 | WP_000999048.1 | host-nuclease inhibitor Gam family protein | - |
| E3S62_RS00560 | 94893..95543 | + | 651 | WP_000840496.1 | ERF family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18062.40 Da Isoelectric Point: 4.6915
>T147958 WP_153157762.1 NZ_CP047803:c90273-89812 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T147958 NZ_CP063380:c4396831-4396418 [Pectobacterium versatile]
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAGCTGCTGTCACTGGTGGTGCATGGCCTCTTAGTATT
ATTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAAATCGTTAAGCGGCCGTGGCTGCTGAAGAATGGCGTGTTGCTGTCATTACAAGCGGTTAACGCTAAAGACAA
GCAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGATGAATGGCGTCACTTGCGTCAGCTTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAGCTGCTGTCACTGGTGGTGCATGGCCTCTTAGTATT
ATTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAAATCGTTAAGCGGCCGTGGCTGCTGAAGAATGGCGTGTTGCTGTCATTACAAGCGGTTAACGCTAAAGACAA
GCAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGATGAATGGCGTCACTTGCGTCAGCTTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT147958 WP_000333630.1 NZ_CP047803:c90600-90286 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT147958 NZ_CP063380:c4397078-4396812 [Pectobacterium versatile]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGTACGTTTGTACGTTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGAAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGTACGTTTGTACGTTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGAAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|