Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 512052..512529 Replicon chromosome
Accession NZ_CP047802
Organism Staphylococcus aureus strain UP_1442

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S67_RS02550 Protein ID WP_000052076.1
Coordinates 512052..512240 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S67_RS02555 Protein ID WP_001059690.1
Coordinates 512269..512529 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S67_RS02520 508046..508567 + 522 WP_000824482.1 hypothetical protein -
E3S67_RS02525 508908..509594 + 687 WP_000141557.1 thermonuclease family protein -
E3S67_RS02530 509951..510151 + 201 WP_001059082.1 cold-shock protein -
E3S67_RS02535 510643..510861 - 219 WP_000005886.1 hypothetical protein -
E3S67_RS02540 510923..511207 - 285 WP_001004399.1 hypothetical protein -
E3S67_RS02545 511295..511864 - 570 WP_001106658.1 hypothetical protein -
E3S67_RS02550 512052..512240 - 189 WP_000052076.1 hypothetical protein Toxin
E3S67_RS02555 512269..512529 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3S67_RS02560 512870..513073 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S67_RS02565 513070..513306 - 237 WP_000349581.1 hypothetical protein -
E3S67_RS02570 513531..514112 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S67_RS02575 514185..514802 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S67_RS02580 514957..515451 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S67_RS02585 515850..516272 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S67_RS02590 516420..517136 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147939 WP_000052076.1 NZ_CP047802:c512240-512052 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147939 NZ_CP063369:4663208-4663543 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147939 WP_001059690.1 NZ_CP047802:c512529-512269 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147939 NZ_CP063369:4662960-4663208 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References