147937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2841143..2841672 Replicon chromosome
Accession NZ_CP047801
Organism Staphylococcus aureus strain UP_248

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3S70_RS14100 Protein ID WP_000621176.1
Coordinates 2841310..2841672 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S70_RS14095 Protein ID WP_000948331.1
Coordinates 2841143..2841313 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S70_RS14065 2836179..2836739 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
E3S70_RS14070 2836948..2837427 + 480 WP_001287082.1 hypothetical protein -
E3S70_RS14075 2837420..2838997 + 1578 WP_001294646.1 PH domain-containing protein -
E3S70_RS14080 2838990..2839481 + 492 WP_001286801.1 PH domain-containing protein -
E3S70_RS14085 2839485..2839844 + 360 WP_000581197.1 holo-ACP synthase -
E3S70_RS14090 2839910..2841058 + 1149 WP_001281140.1 alanine racemase -
E3S70_RS14095 2841143..2841313 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S70_RS14100 2841310..2841672 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S70_RS14105 2842021..2843022 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S70_RS14110 2843141..2843467 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S70_RS14115 2843469..2843948 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S70_RS14120 2843923..2844693 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T147937 WP_000621176.1 NZ_CP047801:2841310-2841672 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T147937 NZ_CP063369:c4393909-4393532 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147937 WP_000948331.1 NZ_CP047801:2841143-2841313 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147937 NZ_CP063369:c4394330-4393956 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References