147928

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1313835..1314312 Replicon chromosome
Accession NZ_CP047801
Organism Staphylococcus aureus strain UP_248

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S70_RS06740 Protein ID WP_000052076.1
Coordinates 1314124..1314312 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S70_RS06735 Protein ID WP_001059690.1
Coordinates 1313835..1314095 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S70_RS06700 1309227..1309943 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3S70_RS06705 1310091..1310513 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S70_RS06710 1310912..1311406 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S70_RS06715 1311562..1312179 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3S70_RS06720 1312252..1312833 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S70_RS06725 1313058..1313294 + 237 WP_000368687.1 hypothetical protein -
E3S70_RS06730 1313291..1313494 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S70_RS06735 1313835..1314095 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S70_RS06740 1314124..1314312 + 189 WP_000052076.1 hypothetical protein Toxin
E3S70_RS06745 1314500..1315069 + 570 WP_001106663.1 hypothetical protein -
E3S70_RS06750 1315157..1315441 + 285 WP_001004401.1 hypothetical protein -
E3S70_RS06755 1315503..1315721 + 219 WP_000005879.1 hypothetical protein -
E3S70_RS06760 1316218..1316418 - 201 WP_001059082.1 cold-shock protein -
E3S70_RS06765 1316775..1317461 - 687 WP_001574556.1 thermonuclease family protein -
E3S70_RS06770 1317802..1318359 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147928 WP_000052076.1 NZ_CP047801:1314124-1314312 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147928 NZ_CP063369:1468881-1468988 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147928 WP_001059690.1 NZ_CP047801:1313835-1314095 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147928 NZ_CP063369:c1468834-1468768 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References