Detailed information of TA system TA147915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2744539..2745068
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: E3S72_RS13675
• Protein ID: WP_000621175.1
• Coordinates: 2744706..2745068 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: E3S72_RS13670
• Protein ID: WP_000948331.1
• Coordinates: 2744539..2744709 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS13640	2739576..2740136	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
E3S72_RS13645	2740344..2740823	+	480	WP_001287087.1	hypothetical protein	-
E3S72_RS13650	2740816..2742399	+	1584	WP_001294626.1	PH domain-containing protein	-
E3S72_RS13655	2742386..2742877	+	492	WP_001205912.1	PH domain-containing protein	-
E3S72_RS13660	2742881..2743240	+	360	WP_000581197.1	holo-ACP synthase	-
E3S72_RS13665	2743306..2744454	+	1149	WP_001281154.1	alanine racemase	-
E3S72_RS13670	2744539..2744709	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
E3S72_RS13675	2744706..2745068	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
E3S72_RS13680	2745418..2746419	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
E3S72_RS13685	2746538..2746864	+	327	WP_001052491.1	anti-sigma factor antagonist	-
E3S72_RS13690	2746866..2747345	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
E3S72_RS13695	2747320..2748090	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T147915 WP_000621175.1 NZ_CP047800:2744706-2745068 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T147915 NZ_CP063362:c6263273-6262749 [Xanthobacter sp. YN2]
GTGCTTGACTGGCGCGAAGAACCCATCGGACGCCATCATGACCGCAAGGCATTCGATTGCGGCACTTCGGAACTGAACGA
ATATCTGCGCCGGCACGCCCGGCAGAACCATGAGGGCGGCGGCTCAAAGACCTTCGTGGCGGTGGCTCCATCCGCTCCCG
AGACGATCTTTGGCTACTACTCCATCAGCCCCGCCTCGATTGCCTTCTCAAAAGTCCCTGCTCCCTTGACCAAGGGCTTG
GGGCGCTACGAGGTCGCCGTGTATCGCCTTGCCCGTCTGGCTGTTGCGCTTCCACAACAGGGTCAGGGACTTGGGGGCGA
TCTTTTGCTTGCGGCGGGTGCGAGGGCGCTTGCCGTAGCCGCTCAGGTCGGAGGCGTGGCGCTGGCTATCGACGCCAAGG
ACGAGAAGGCGGCGCGCTGGTACAAGCGCTTCGGTGCGATGCCCTTGCTCGACAGCAGCCCGCTTAGCCTGATCCTGCCA
TTCAAGACCATCATCGATGCTCTGGACGCCGCGCAGGGCGAATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT147915 WP_000948331.1 NZ_CP047800:2744539-2744709 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT147915 NZ_CP063362:c6263556-6263266 [Xanthobacter sp. YN2]
ATGGCCCAGACACAATCCAGTCGTGACGACCGCATCGAGTTGCGCACCACGCGCGACGAAAAGCGGCTTCTCACCGCCGC
CGCTGCGCATGAGCGGCTGGACCTGACCAGCTTCATCATGCGCGCCGCCCTGCCGGCCGCGCGCGATGTGGTCGAGAACG
CGGAACGCATCTCGCTTTCGGAGCGGGATTCCCTGCGCGTGCTCGACCTTCTGGAAAATCCGCCGGCCCCGACGCCAGCT
CTGCTTGCCGCAGCGCGCCGCCGCATCGCCCGAGGCGGCAAGGGTGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1