147904

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1210144..1210621 Replicon chromosome
Accession NZ_CP047800
Organism Staphylococcus aureus strain UP_296

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S72_RS06150 Protein ID WP_000052076.1
Coordinates 1210433..1210621 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S72_RS06145 Protein ID WP_001059690.1
Coordinates 1210144..1210404 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S72_RS06110 1205537..1206253 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S72_RS06115 1206401..1206823 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S72_RS06120 1207222..1207716 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S72_RS06125 1207871..1208488 + 618 WP_160198880.1 LysE/ArgO family amino acid transporter -
E3S72_RS06130 1208561..1209142 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S72_RS06135 1209367..1209603 + 237 WP_000349581.1 hypothetical protein -
E3S72_RS06140 1209600..1209803 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S72_RS06145 1210144..1210404 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S72_RS06150 1210433..1210621 + 189 WP_000052076.1 hypothetical protein Toxin
E3S72_RS06155 1210809..1211378 + 570 WP_001106654.1 hypothetical protein -
E3S72_RS06160 1211466..1211750 + 285 WP_001004399.1 hypothetical protein -
E3S72_RS06165 1211812..1212030 + 219 WP_000005886.1 hypothetical protein -
E3S72_RS06170 1212522..1212722 - 201 WP_001059082.1 cold-shock protein -
E3S72_RS06175 1213079..1213765 - 687 WP_000141557.1 thermonuclease family protein -
E3S72_RS06180 1214109..1214630 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147904 WP_000052076.1 NZ_CP047800:1210433-1210621 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147904 NZ_CP063356:1887305-1887655 [Anaerobacillus isosaccharinicus]
ATTGTTGTAAAACGTGGCGACGTTTATTTTGCTGATCTCTCACCAGTTGTCGGTTCAGAGCAGGGGGGAGTAAGGCCAGT
TCTCATCATTCAAAATGATATCGGAAATCGGTTTAGCCCAACAGTCATCGTCGCAGCAATTACAGCTCAGATTCAGAAGG
CCAAACTACCAACACATGTTGAAATTAATGCAAAGCGTTATGGCTTTGATCGGGATTCTGTTATCTTGTTAGAACAAGTT
CGTACAATTGATAAACAACGTCTAACTGATAAAATTACTCATTTAGATGACGACATGATGTCCCGAGTTAATGAGGCACT
ACAGATTAGTTTAGGACTAATTGATTTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147904 WP_001059690.1 NZ_CP047800:1210144-1210404 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147904 NZ_CP063356:1887020-1887298 [Anaerobacillus isosaccharinicus]
GTGTCTGCTAACACAAAGAGAATCACGGTGAGCTTACCACAACATTTATTAAATGAGGTTGATGGCTTGATTAAACGAGA
AAATGTTAACCGAAGTGAATTTATTTCCCAAGCTACAAAAGAATACCTTCGTGAAAAGAAGAAACGTCAAATTCGCGAAA
CGATGCAACAGGGTTATATGGAAATGGCTAAAATTAATTTGAATATTGCTGCTGAAGCTTTTCTTGCGGAAGAGGAAGCG
GAGCACACACGCACACTAGACTTAGTTAGTGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References