Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1187552..1188343 | Replicon | chromosome |
| Accession | NZ_CP047800 | ||
| Organism | Staphylococcus aureus strain UP_296 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | E3S72_RS06000 | Protein ID | WP_031783010.1 |
| Coordinates | 1187879..1188343 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | E3S72_RS05995 | Protein ID | WP_000333630.1 |
| Coordinates | 1187552..1187866 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S72_RS05940 | 1182958..1183731 | - | 774 | WP_061713844.1 | AAA family ATPase | - |
| E3S72_RS05945 | 1183731..1184210 | - | 480 | WP_000002516.1 | siphovirus Gp157 family protein | - |
| E3S72_RS05950 | 1184225..1184485 | - | 261 | WP_061713843.1 | DUF1108 family protein | - |
| E3S72_RS05955 | 1184549..1184863 | - | 315 | WP_040968664.1 | helix-turn-helix transcriptional regulator | - |
| E3S72_RS05960 | 1184868..1185038 | - | 171 | WP_000048123.1 | DUF1270 domain-containing protein | - |
| E3S72_RS05965 | 1185031..1185252 | - | 222 | WP_061713842.1 | hypothetical protein | - |
| E3S72_RS05970 | 1185266..1185715 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| E3S72_RS05975 | 1185755..1185979 | - | 225 | WP_061713840.1 | hypothetical protein | - |
| E3S72_RS05980 | 1185980..1186759 | - | 780 | WP_029625612.1 | phage antirepressor KilAC domain-containing protein | - |
| E3S72_RS05985 | 1186947..1187150 | - | 204 | WP_000394020.1 | hypothetical protein | - |
| E3S72_RS05990 | 1187164..1187400 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| E3S72_RS05995 | 1187552..1187866 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| E3S72_RS06000 | 1187879..1188343 | + | 465 | WP_031783010.1 | toxin | Toxin |
| E3S72_RS06005 | 1188375..1189280 | + | 906 | WP_000391592.1 | hypothetical protein | - |
| E3S72_RS06010 | 1189217..1189417 | - | 201 | WP_000143212.1 | excisionase | - |
| E3S72_RS06015 | 1189529..1190578 | + | 1050 | WP_061713839.1 | site-specific integrase | - |
| E3S72_RS06020 | 1190646..1192043 | - | 1398 | WP_001074405.1 | Fe-S cluster assembly protein SufB | - |
| E3S72_RS06025 | 1192194..1192658 | - | 465 | WP_001010508.1 | SUF system NifU family Fe-S cluster assembly protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1141279..1192043 | 50764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18142.50 Da Isoelectric Point: 4.7927
>T147903 WP_031783010.1 NZ_CP047800:1187879-1188343 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
Download Length: 465 bp
>T147903 NZ_CP063354:c4588754-4588401 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGCGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGCGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT147903 WP_000333630.1 NZ_CP047800:1187552-1187866 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT147903 NZ_CP063354:c4588396-4588094 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCTGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCTGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|