Detailed information of TA system TA147900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 131494..132270
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: E3S72_RS00820
• Protein ID: WP_000031108.1
• Coordinates: 132118..132270 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S72_RS00815
• Protein ID: WP_001251224.1
• Coordinates: 131494..132093 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS00795	127410..128867	+	1458	WP_031875741.1	ABC transporter permease subunit	-
E3S72_RS00800	128860..129582	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S72_RS00805	129733..130860	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S72_RS00810	130865..131335	+	471	WP_160198862.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S72_RS00815	131494..132093	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S72_RS00820	132118..132270	+	153	WP_000031108.1	hypothetical protein	Toxin
E3S72_RS00825	132818..133213	+	396	WP_000901023.1	hypothetical protein	-
E3S72_RS00830	133409..134794	+	1386	WP_000116228.1	class II fumarate hydratase	-
E3S72_RS00835	135247..136068	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T147900 WP_000031108.1 NZ_CP047800:132118-132270 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T147900 NZ_CP063354:2889961-2890269 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGCCCTCTCGACCCGGTTAATGATTCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGCTTATGCCCGG
AGATTGAGGTAAACGGCGAAAAGTTTCTCGTTATGACCCATGAGATGGCTGCCGTACGTATTTCACAGCTCGGGAAGGCC
GTTGGTAATGCCAATGAGCATAGGAATCAAATTAAAGCTGCCATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147900 WP_001251224.1 NZ_CP047800:131494-132093 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147900 NZ_CP063354:2889722-2889958 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACAGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4