Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2746761..2747290 Replicon chromosome
Accession NZ_CP047799
Organism Staphylococcus aureus strain UP_322

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3S73_RS13540 Protein ID WP_000621176.1
Coordinates 2746928..2747290 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S73_RS13535 Protein ID WP_000948331.1
Coordinates 2746761..2746931 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S73_RS13505 2741797..2742357 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
E3S73_RS13510 2742566..2743045 + 480 WP_001287082.1 hypothetical protein -
E3S73_RS13515 2743038..2744615 + 1578 WP_001294646.1 PH domain-containing protein -
E3S73_RS13520 2744608..2745099 + 492 WP_001286801.1 PH domain-containing protein -
E3S73_RS13525 2745103..2745462 + 360 WP_000581197.1 holo-ACP synthase -
E3S73_RS13530 2745528..2746676 + 1149 WP_001281140.1 alanine racemase -
E3S73_RS13535 2746761..2746931 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S73_RS13540 2746928..2747290 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S73_RS13545 2747639..2748640 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S73_RS13550 2748759..2749085 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S73_RS13555 2749087..2749566 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S73_RS13560 2749541..2750311 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T147896 WP_000621176.1 NZ_CP047799:2746928-2747290 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T147896 NZ_CP063354:c568737-568462 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCTGAGGCTTTGTTACAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCCGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147896 WP_000948331.1 NZ_CP047799:2746761-2746931 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147896 NZ_CP063354:c568934-568743 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCTCCCGTATCCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References