Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1676823..1677355 Replicon chromosome
Accession NZ_CP047799
Organism Staphylococcus aureus strain UP_322

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag E3S73_RS08415 Protein ID WP_123090134.1
Coordinates 1676823..1677143 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag E3S73_RS08420 Protein ID WP_001058492.1
Coordinates 1677146..1677355 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S73_RS08385 1671976..1672317 - 342 WP_001190616.1 hypothetical protein -
E3S73_RS08390 1672855..1673496 - 642 WP_123090293.1 pathogenicity island protein -
E3S73_RS08395 1673498..1673761 - 264 WP_001804819.1 hypothetical protein -
E3S73_RS08400 1673763..1674125 - 363 WP_001039165.1 hypothetical protein -
E3S73_RS08405 1674404..1675873 - 1470 WP_053040304.1 virulence-associated E family protein -
E3S73_RS08410 1675890..1676759 - 870 WP_053040303.1 primase alpha helix C-terminal domain-containing protein -
E3S73_RS08415 1676823..1677143 - 321 WP_123090134.1 DUF1474 family protein Toxin
E3S73_RS08420 1677146..1677355 - 210 WP_001058492.1 hypothetical protein Antitoxin
E3S73_RS08425 1677348..1677494 - 147 WP_000784885.1 hypothetical protein -
E3S73_RS08430 1677506..1677778 - 273 WP_053040301.1 helix-turn-helix domain-containing protein -
E3S73_RS08435 1677779..1677991 - 213 WP_053040300.1 helix-turn-helix transcriptional regulator -
E3S73_RS08440 1678141..1678875 + 735 WP_000142630.1 helix-turn-helix domain-containing protein -
E3S73_RS08445 1679174..1680388 + 1215 WP_123090135.1 site-specific integrase -
E3S73_RS08450 1680389..1681222 + 834 WP_180372434.1 type II toxin-antitoxin system PemK/MazF family toxin -
E3S73_RS08455 1681454..1681696 - 243 WP_000897044.1 30S ribosomal protein S18 -
E3S73_RS08460 1681748..1682251 - 504 WP_000934799.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1661556..1686311 24755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12636.18 Da        Isoelectric Point: 4.8637

>T147887 WP_123090134.1 NZ_CP047799:c1677143-1676823 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEGRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

>T147887 NZ_CP063349:c3337994-3337887 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAATCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT147887 WP_001058492.1 NZ_CP047799:c1677355-1677146 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT147887 NZ_CP063349:3338047-3338108 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References