Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1216317..1216794 Replicon chromosome
Accession NZ_CP047799
Organism Staphylococcus aureus strain UP_322

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S73_RS06145 Protein ID WP_000052076.1
Coordinates 1216606..1216794 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S73_RS06140 Protein ID WP_001059690.1
Coordinates 1216317..1216577 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S73_RS06105 1211709..1212425 - 717 WP_000150022.1 type I 3-dehydroquinate dehydratase -
E3S73_RS06110 1212573..1212995 + 423 WP_123090159.1 organic hydroperoxide resistance protein -
E3S73_RS06115 1213394..1213888 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S73_RS06120 1214044..1214661 + 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
E3S73_RS06125 1214734..1215315 - 582 WP_201748439.1 phosphoglycerate mutase family protein -
E3S73_RS06130 1215540..1215776 + 237 WP_000368687.1 hypothetical protein -
E3S73_RS06135 1215773..1215976 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S73_RS06140 1216317..1216577 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S73_RS06145 1216606..1216794 + 189 WP_000052076.1 hypothetical protein Toxin
E3S73_RS06150 1216982..1217551 + 570 WP_001106663.1 hypothetical protein -
E3S73_RS06155 1217639..1217923 + 285 WP_001004401.1 hypothetical protein -
E3S73_RS06160 1217985..1218203 + 219 WP_000005879.1 hypothetical protein -
E3S73_RS06165 1218700..1218900 - 201 WP_001059082.1 cold-shock protein -
E3S73_RS06170 1219257..1219943 - 687 WP_001574556.1 thermonuclease family protein -
E3S73_RS06175 1220284..1220841 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147886 WP_000052076.1 NZ_CP047799:1216606-1216794 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147886 NZ_CP063349:c3337459-3337352 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147886 WP_001059690.1 NZ_CP047799:1216317-1216577 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147886 NZ_CP063349:3337507-3337573 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References