Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2658119..2658633 Replicon chromosome
Accession NZ_CP047798
Organism Staphylococcus aureus strain UP_378

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag E3S75_RS13095 Protein ID WP_000581795.1
Coordinates 2658424..2658633 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag E3S75_RS13090 Protein ID WP_000138930.1
Coordinates 2658119..2658412 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S75_RS13070 2653645..2654286 + 642 WP_000483162.1 thiamine phosphate synthase -
E3S75_RS13075 2654372..2655244 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S75_RS13080 2655794..2656441 - 648 WP_001187625.1 HD domain-containing protein -
E3S75_RS13085 2656469..2657953 - 1485 WP_160195243.1 cardiolipin synthase -
E3S75_RS13090 2658119..2658412 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S75_RS13095 2658424..2658633 + 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
E3S75_RS13100 2658761..2658898 + 138 WP_000828354.1 hypothetical protein -
E3S75_RS13105 2659162..2660364 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S75_RS13110 2660682..2661752 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
E3S75_RS13115 2661767..2663125 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T147877 WP_000581795.1 NZ_CP047798:2658424-2658633 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147877 NZ_CP063349:c295986-295579 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT147877 WP_000138930.1 NZ_CP047798:2658119-2658412 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147877 NZ_CP063349:c296233-295967 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References