Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1180093..1180570 Replicon chromosome
Accession NZ_CP047798
Organism Staphylococcus aureus strain UP_378

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S75_RS05970 Protein ID WP_000052076.1
Coordinates 1180382..1180570 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S75_RS05965 Protein ID WP_001059690.1
Coordinates 1180093..1180353 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S75_RS05930 1175486..1176202 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S75_RS05935 1176350..1176772 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S75_RS05940 1177171..1177665 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S75_RS05945 1177821..1178438 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S75_RS05950 1178511..1179092 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S75_RS05955 1179316..1179552 + 237 WP_000368687.1 hypothetical protein -
E3S75_RS05960 1179549..1179752 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S75_RS05965 1180093..1180353 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S75_RS05970 1180382..1180570 + 189 WP_000052076.1 hypothetical protein Toxin
E3S75_RS05975 1180758..1181327 + 570 WP_001106662.1 hypothetical protein -
E3S75_RS05980 1181415..1181687 + 273 WP_001004400.1 hypothetical protein -
E3S75_RS05985 1181760..1181978 + 219 WP_000005884.1 hypothetical protein -
E3S75_RS05990 1182475..1182675 - 201 WP_001059082.1 cold-shock protein -
E3S75_RS05995 1183032..1183718 - 687 WP_001622483.1 thermonuclease family protein -
E3S75_RS06000 1184059..1184580 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147874 WP_000052076.1 NZ_CP047798:1180382-1180570 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147874 NZ_CP063343:109067-109447 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147874 WP_001059690.1 NZ_CP047798:1180093-1180353 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147874 NZ_CP063343:108846-109067 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References