Detailed information of TA system TA147873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 119159..119935
• Replicon: chromosome
• Accession: NZ_CP047798
• Organism: Staphylococcus aureus strain UP_378

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3S75_RS00760
• Protein ID: WP_000031109.1
• Coordinates: 119783..119935 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S75_RS00755
• Protein ID: WP_001251224.1
• Coordinates: 119159..119758 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S75_RS00735	115075..116532	+	1458	WP_000649916.1	ABC transporter permease subunit	-
E3S75_RS00740	116525..117247	+	723	WP_201750756.1	amino acid ABC transporter ATP-binding protein	-
E3S75_RS00745	117398..118525	+	1128	WP_201750753.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S75_RS00750	118530..119000	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S75_RS00755	119159..119758	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S75_RS00760	119783..119935	+	153	WP_000031109.1	hypothetical protein	Toxin
E3S75_RS00765	120875..121270	+	396	WP_000901019.1	hypothetical protein	-
E3S75_RS00770	121466..122851	+	1386	WP_000116239.1	class II fumarate hydratase	-
E3S75_RS00775	123308..124129	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T147873 WP_000031109.1 NZ_CP047798:119783-119935 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T147873 NZ_CP063343:c75601-75443 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147873 WP_001251224.1 NZ_CP047798:119159-119758 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147873 NZ_CP063343:c75869-75645 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin

• AlphaFold DB: W8U4V4