Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2715922..2716436 Replicon chromosome
Accession NZ_CP047797
Organism Staphylococcus aureus strain UP_426

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S77_RS13275 Protein ID WP_000581792.1
Coordinates 2716227..2716436 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S77_RS13270 Protein ID WP_000138932.1
Coordinates 2715922..2716215 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S77_RS13245 2711367..2712008 + 642 WP_000483160.1 thiamine phosphate synthase -
E3S77_RS13250 2712094..2712966 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S77_RS13260 2713597..2714244 - 648 WP_001187620.1 HD domain-containing protein -
E3S77_RS13265 2714272..2715756 - 1485 WP_000571551.1 cardiolipin synthase -
E3S77_RS13270 2715922..2716215 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S77_RS13275 2716227..2716436 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S77_RS13280 2716564..2716701 + 138 WP_000828354.1 hypothetical protein -
E3S77_RS13285 2716965..2718167 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S77_RS13290 2718485..2719555 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S77_RS13295 2719570..2720928 + 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147867 WP_000581792.1 NZ_CP047797:2716227-2716436 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147867 NZ_CP063341:3725383-3725661 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147867 WP_000138932.1 NZ_CP047797:2715922-2716215 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147867 NZ_CP063341:3725120-3725380 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References