Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1260345..1260822 Replicon chromosome
Accession NZ_CP047797
Organism Staphylococcus aureus strain UP_426

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S77_RS06335 Protein ID WP_000052076.1
Coordinates 1260634..1260822 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S77_RS06330 Protein ID WP_001059690.1
Coordinates 1260345..1260605 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S77_RS06295 1255736..1256452 - 717 WP_031927536.1 type I 3-dehydroquinate dehydratase -
E3S77_RS06300 1256600..1257022 + 423 WP_031927537.1 organic hydroperoxide resistance protein -
E3S77_RS06305 1257421..1257915 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
E3S77_RS06310 1258072..1258689 + 618 WP_047213256.1 LysE/ArgO family amino acid transporter -
E3S77_RS06315 1258762..1259343 - 582 WP_001140691.1 phosphoglycerate mutase family protein -
E3S77_RS06320 1259568..1259804 + 237 WP_000368687.1 hypothetical protein -
E3S77_RS06325 1259801..1260004 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S77_RS06330 1260345..1260605 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S77_RS06335 1260634..1260822 + 189 WP_000052076.1 hypothetical protein Toxin
E3S77_RS06340 1261010..1261579 + 570 WP_001106648.1 hypothetical protein -
E3S77_RS06345 1261667..1261951 + 285 WP_001004397.1 hypothetical protein -
E3S77_RS06350 1262013..1262231 + 219 WP_000005883.1 hypothetical protein -
E3S77_RS06355 1262728..1262928 - 201 WP_001059082.1 cold-shock protein -
E3S77_RS06360 1263285..1263971 - 687 WP_000141556.1 thermonuclease family protein -
E3S77_RS06365 1264312..1264794 - 483 WP_000824492.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147859 WP_000052076.1 NZ_CP047797:1260634-1260822 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147859 NZ_CP063341:2036487-2036590 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147859 WP_001059690.1 NZ_CP047797:1260345-1260605 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147859 NZ_CP063341:c2036628-2036357 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ATGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References