Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2443188..2443964 Replicon chromosome
Accession NZ_CP047796
Organism Staphylococcus aureus strain UP_462

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E3S78_RS11955 Protein ID WP_000031108.1
Coordinates 2443812..2443964 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag E3S78_RS11950 Protein ID WP_001251219.1
Coordinates 2443188..2443787 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S78_RS11930 2439104..2440561 + 1458 WP_000649898.1 ABC transporter permease subunit -
E3S78_RS11935 2440554..2441276 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E3S78_RS11940 2441427..2442554 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
E3S78_RS11945 2442559..2443029 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E3S78_RS11950 2443188..2443787 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
E3S78_RS11955 2443812..2443964 + 153 WP_000031108.1 hypothetical protein Toxin
E3S78_RS11960 2444565..2444960 + 396 WP_000901019.1 hypothetical protein -
E3S78_RS11965 2445156..2446541 + 1386 WP_000116227.1 class II fumarate hydratase -
E3S78_RS11970 2446997..2447818 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T147848 WP_000031108.1 NZ_CP047796:2443812-2443964 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T147848 NZ_CP063341:198097-198204 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT147848 WP_001251219.1 NZ_CP047796:2443188-2443787 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT147848 NZ_CP063341:c198048-197985 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References