Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2226905..2227419 Replicon chromosome
Accession NZ_CP047796
Organism Staphylococcus aureus strain UP_462

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3S78_RS10675 Protein ID WP_000581791.1
Coordinates 2227210..2227419 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3S78_RS10670 Protein ID WP_000138934.1
Coordinates 2226905..2227198 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S78_RS10640 2222368..2223009 + 642 WP_000483150.1 thiamine phosphate synthase -
E3S78_RS10645 2223095..2223967 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S78_RS10650 2224124..2224423 - 300 WP_001793952.1 hypothetical protein -
E3S78_RS10660 2224580..2225227 - 648 WP_001187612.1 HD domain-containing protein -
E3S78_RS10665 2225255..2226739 - 1485 WP_000571560.1 cardiolipin synthase -
E3S78_RS10670 2226905..2227198 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S78_RS10675 2227210..2227419 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3S78_RS10680 2227547..2227684 + 138 WP_000828354.1 hypothetical protein -
E3S78_RS10685 2228096..2228779 + 684 Protein_2092 transposase -
E3S78_RS10690 2228940..2230142 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S78_RS10695 2230460..2231530 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147845 WP_000581791.1 NZ_CP047796:2227210-2227419 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147845 NZ_CP063337:c36634-36218 [Escherichia coli]
GTGAAAAAGACTTTTATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGAGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGCCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147845 WP_000138934.1 NZ_CP047796:2226905-2227198 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147845 NZ_CP063337:c36861-36631 [Escherichia coli]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References