Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 717312..717789 Replicon chromosome
Accession NZ_CP047796
Organism Staphylococcus aureus strain UP_462

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S78_RS03385 Protein ID WP_000052076.1
Coordinates 717601..717789 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S78_RS03380 Protein ID WP_001059690.1
Coordinates 717312..717572 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S78_RS03345 712704..713420 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3S78_RS03350 713568..713990 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S78_RS03355 714389..714883 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S78_RS03360 715039..715656 + 618 WP_160176162.1 LysE/ArgO family amino acid transporter -
E3S78_RS03365 715729..716310 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S78_RS03370 716535..716771 + 237 WP_000368687.1 hypothetical protein -
E3S78_RS03375 716768..716971 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S78_RS03380 717312..717572 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S78_RS03385 717601..717789 + 189 WP_000052076.1 hypothetical protein Toxin
E3S78_RS03390 717977..718546 + 570 WP_001106663.1 hypothetical protein -
E3S78_RS03395 718634..718918 + 285 WP_001004401.1 hypothetical protein -
E3S78_RS03400 718980..719198 + 219 WP_000005879.1 hypothetical protein -
E3S78_RS03405 719695..719895 - 201 WP_001059082.1 cold-shock protein -
E3S78_RS03410 720252..720938 - 687 WP_001574556.1 thermonuclease family protein -
E3S78_RS03415 721279..721836 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147837 WP_000052076.1 NZ_CP047796:717601-717789 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147837 NZ_CP063332:c3937075-3936797 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147837 WP_001059690.1 NZ_CP047796:717312-717572 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147837 NZ_CP063332:c3937338-3937078 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References