Detailed information of TA system TA147826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1862443..1863219
• Replicon: chromosome
• Accession: NZ_CP047795
• Organism: Staphylococcus aureus strain UP_490

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3S79_RS08945
• Protein ID: WP_000031109.1
• Coordinates: 1862443..1862595 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S79_RS08950
• Protein ID: WP_001251224.1
• Coordinates: 1862620..1863219 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S79_RS08930	1858362..1859183	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
E3S79_RS08935	1859640..1861025	-	1386	WP_000116239.1	class II fumarate hydratase	-
E3S79_RS08940	1861221..1861616	-	396	WP_000901019.1	hypothetical protein	-
E3S79_RS08945	1862443..1862595	-	153	WP_000031109.1	hypothetical protein	Toxin
E3S79_RS08950	1862620..1863219	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S79_RS08955	1863378..1863848	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S79_RS08960	1863853..1864980	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S79_RS08965	1865131..1865853	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S79_RS08970	1865846..1867303	-	1458	WP_000649916.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T147826 WP_000031109.1 NZ_CP047795:c1862595-1862443 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T147826 NZ_CP063332:c898866-898763 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147826 WP_001251224.1 NZ_CP047795:c1863219-1862620 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147826 NZ_CP063332:898725-898996 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: W8U4V4