Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 836249..836726 Replicon chromosome
Accession NZ_CP047795
Organism Staphylococcus aureus strain UP_490

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S79_RS04000 Protein ID WP_000052076.1
Coordinates 836249..836437 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S79_RS04005 Protein ID WP_001059690.1
Coordinates 836466..836726 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S79_RS03970 832238..832759 + 522 WP_000824479.1 hypothetical protein -
E3S79_RS03975 833100..833787 + 688 Protein_769 thermonuclease family protein -
E3S79_RS03980 834144..834344 + 201 WP_001059082.1 cold-shock protein -
E3S79_RS03985 834841..835059 - 219 WP_000005884.1 hypothetical protein -
E3S79_RS03990 835132..835404 - 273 WP_001004400.1 hypothetical protein -
E3S79_RS03995 835492..836061 - 570 WP_001106662.1 hypothetical protein -
E3S79_RS04000 836249..836437 - 189 WP_000052076.1 hypothetical protein Toxin
E3S79_RS04005 836466..836726 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3S79_RS04010 837067..837270 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S79_RS04015 837267..837503 - 237 WP_000368687.1 hypothetical protein -
E3S79_RS04020 837727..838308 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S79_RS04025 838381..838998 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S79_RS04030 839154..839648 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S79_RS04035 840047..840469 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S79_RS04040 840617..841333 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell / vWbp 802062..839648 37586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147825 WP_000052076.1 NZ_CP047795:c836437-836249 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147825 NZ_CP063332:c614358-614071 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147825 WP_001059690.1 NZ_CP047795:c836726-836466 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147825 NZ_CP063332:c614597-614358 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References