Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2761331..2761860 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3S81_RS13560 Protein ID WP_000621175.1
Coordinates 2761498..2761860 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S81_RS13555 Protein ID WP_000948331.1
Coordinates 2761331..2761501 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS13525 2756367..2756927 + 561 WP_001092403.1 K(+)-transporting ATPase subunit C -
E3S81_RS13530 2757136..2757615 + 480 WP_001287075.1 hypothetical protein -
E3S81_RS13535 2757608..2759191 + 1584 WP_001294640.1 PH domain-containing protein -
E3S81_RS13540 2759178..2759669 + 492 WP_001205919.1 PH domain-containing protein -
E3S81_RS13545 2759673..2760032 + 360 WP_000581198.1 holo-ACP synthase -
E3S81_RS13550 2760098..2761246 + 1149 WP_001281143.1 alanine racemase -
E3S81_RS13555 2761331..2761501 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S81_RS13560 2761498..2761860 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S81_RS13565 2762210..2763211 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S81_RS13570 2763330..2763656 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S81_RS13575 2763658..2764137 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S81_RS13580 2764112..2764882 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T147822 WP_000621175.1 NZ_CP047794:2761498-2761860 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T147822 NZ_CP063332:c203648-203541 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147822 WP_000948331.1 NZ_CP047794:2761331-2761501 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147822 NZ_CP063332:203695-203761 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References