Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1263268..1263745 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S81_RS06380 Protein ID WP_000052076.1
Coordinates 1263557..1263745 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S81_RS06375 Protein ID WP_001059690.1
Coordinates 1263268..1263528 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS06340 1258659..1259375 - 717 WP_031927536.1 type I 3-dehydroquinate dehydratase -
E3S81_RS06345 1259523..1259945 + 423 WP_031927537.1 organic hydroperoxide resistance protein -
E3S81_RS06350 1260344..1260838 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
E3S81_RS06355 1260995..1261612 + 618 WP_047213256.1 LysE/ArgO family amino acid transporter -
E3S81_RS06360 1261685..1262266 - 582 WP_001140691.1 phosphoglycerate mutase family protein -
E3S81_RS06365 1262491..1262727 + 237 WP_000368687.1 hypothetical protein -
E3S81_RS06370 1262724..1262927 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S81_RS06375 1263268..1263528 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S81_RS06380 1263557..1263745 + 189 WP_000052076.1 hypothetical protein Toxin
E3S81_RS06385 1263933..1264502 + 570 WP_001106648.1 hypothetical protein -
E3S81_RS06390 1264590..1264874 + 285 WP_001004397.1 hypothetical protein -
E3S81_RS06395 1264936..1265154 + 219 WP_000005883.1 hypothetical protein -
E3S81_RS06400 1265651..1265851 - 201 WP_001059082.1 cold-shock protein -
E3S81_RS06405 1266208..1266894 - 687 WP_000141556.1 thermonuclease family protein -
E3S81_RS06410 1267235..1267717 - 483 WP_000824492.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Protein of unknown function DUF6290

(3-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147812 WP_000052076.1 NZ_CP047794:1263557-1263745 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147812 NZ_CP063310:c2022622-2022368 [Eggerthella sp. HF-1101]
CTGACGAGCGGCGCGGTAAAGCAGCTGCGGAGCCTCGATCGTAAAACCCTGTTGCTGGTATCGGAGCTGATCGAGCGCCT
TGACGGGTGCGAGAACCCCTGCACGCTCCCCAACGCGAAGAAACTCCAGGGAGTGAAGAACGGTTGGCGTTGGCGTACCG
GGACGTATCGCGTGCTCGGCACGGTCGACGGCGACCGCATAACGATCGAAGTATTCAAGATCGGACACCGTCGAGACGTA
TACCGCAACCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147812 WP_001059690.1 NZ_CP047794:1263268-1263528 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147812 NZ_CP063310:c2022868-2022641 [Eggerthella sp. HF-1101]
ATGGCCATGACGGCATCGGCTATTCGGTTCGAACCGAACGAGAAAGAATGGATTGCCGCATTCGCCGAGATGAACGGTTC
CACGTTTTCCGCGCAAGTGCGCCAGTGGACGCTCGAGCGTCTCGAGGACGAGCTTGACGCTCGGGACCTTTCGCAGGCGA
TCGAGGAAGACGACGGTACGCGCATTTCCTGGAGCAAGGCCAAGGCCGATCTCGGGCTGGCGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References