Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 153850..154647 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag E3S81_RS00950 Protein ID WP_000525009.1
Coordinates 153850..154311 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag E3S81_RS00955 Protein ID WP_001260487.1
Coordinates 154324..154647 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS00895 150359..150913 + 555 WP_000132893.1 alpha/beta hydrolase -
E3S81_RS00940 152206..153255 - 1050 WP_000146088.1 site-specific integrase -
E3S81_RS00945 153317..153832 - 516 WP_031790084.1 hypothetical protein -
E3S81_RS00950 153850..154311 - 462 WP_000525009.1 hypothetical protein Toxin
E3S81_RS00955 154324..154647 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
E3S81_RS00960 154811..155059 + 249 WP_000272859.1 helix-turn-helix domain-containing protein -
E3S81_RS00965 155072..155515 + 444 WP_000435360.1 hypothetical protein -
E3S81_RS00970 155530..155670 + 141 WP_000939495.1 hypothetical protein -
E3S81_RS00975 155663..155872 - 210 WP_000772137.1 hypothetical protein -
E3S81_RS00980 155929..156642 + 714 WP_031925041.1 ORF6C domain-containing protein -
E3S81_RS00985 156655..156864 + 210 WP_000455728.1 hypothetical protein -
E3S81_RS00990 156878..157039 + 162 WP_031928972.1 DUF1270 family protein -
E3S81_RS00995 157133..157393 + 261 WP_000291089.1 DUF1108 family protein -
E3S81_RS01000 157406..157942 + 537 WP_000999048.1 host-nuclease inhibitor Gam family protein -
E3S81_RS01005 157943..158593 + 651 WP_000840496.1 ERF family protein -
E3S81_RS01010 158590..159033 + 444 WP_001099010.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlgA / lukD 139753..227522 87769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T147811 WP_000525009.1 NZ_CP047794:c154311-153850 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T147811 NZ_CP063303:3334705-3334908 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT147811 WP_001260487.1 NZ_CP047794:c154647-154324 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT147811 NZ_CP063303:3334288-3334656 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References