Detailed information of TA system TA147811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 153850..154647
• Replicon: chromosome
• Accession: NZ_CP047794
• Organism: Staphylococcus aureus strain UP_551

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6B0C7N0
• Locus tag: E3S81_RS00950
• Protein ID: WP_000525009.1
• Coordinates: 153850..154311 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: E3S81_RS00955
• Protein ID: WP_001260487.1
• Coordinates: 154324..154647 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S81_RS00895	150359..150913	+	555	WP_000132893.1	alpha/beta hydrolase	-
E3S81_RS00940	152206..153255	-	1050	WP_000146088.1	site-specific integrase	-
E3S81_RS00945	153317..153832	-	516	WP_031790084.1	hypothetical protein	-
E3S81_RS00950	153850..154311	-	462	WP_000525009.1	hypothetical protein	Toxin
E3S81_RS00955	154324..154647	-	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
E3S81_RS00960	154811..155059	+	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
E3S81_RS00965	155072..155515	+	444	WP_000435360.1	hypothetical protein	-
E3S81_RS00970	155530..155670	+	141	WP_000939495.1	hypothetical protein	-
E3S81_RS00975	155663..155872	-	210	WP_000772137.1	hypothetical protein	-
E3S81_RS00980	155929..156642	+	714	WP_031925041.1	ORF6C domain-containing protein	-
E3S81_RS00985	156655..156864	+	210	WP_000455728.1	hypothetical protein	-
E3S81_RS00990	156878..157039	+	162	WP_031928972.1	DUF1270 family protein	-
E3S81_RS00995	157133..157393	+	261	WP_000291089.1	DUF1108 family protein	-
E3S81_RS01000	157406..157942	+	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
E3S81_RS01005	157943..158593	+	651	WP_000840496.1	ERF family protein	-
E3S81_RS01010	158590..159033	+	444	WP_001099010.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	139753..227522	87769

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18060.39 Da
• Isoelectric Point: 4.5941

>T147811 WP_000525009.1 NZ_CP047794:c154311-153850 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T147811 NZ_CP063303:3334705-3334908 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT147811 WP_001260487.1 NZ_CP047794:c154647-154324 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT147811 NZ_CP063303:3334288-3334656 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Structures

Toxin

• AlphaFold DB: A0A6B0C7N0

Antitoxin

• AlphaFold DB: A0A0C2LD36