Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 123616..124392 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name tsbT Uniprot ID A0A380DXA2
Locus tag E3S81_RS00775 Protein ID WP_000031110.1
Coordinates 124240..124392 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag E3S81_RS00770 Protein ID WP_001251219.1
Coordinates 123616..124215 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS00750 119532..120989 + 1458 WP_031927464.1 ABC transporter permease subunit -
E3S81_RS00755 120982..121704 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E3S81_RS00760 121855..122982 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
E3S81_RS00765 122987..123457 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E3S81_RS00770 123616..124215 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
E3S81_RS00775 124240..124392 + 153 WP_000031110.1 hypothetical protein Toxin
E3S81_RS00780 125052..125447 + 396 WP_000901023.1 hypothetical protein -
E3S81_RS00785 125643..127028 + 1386 WP_160199079.1 class II fumarate hydratase -
E3S81_RS00790 127479..128300 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5964.34 Da        Isoelectric Point: 3.9953

>T147810 WP_000031110.1 NZ_CP047794:124240-124392 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T147810 NZ_CP063303:c2992321-2992229 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT147810 WP_001251219.1 NZ_CP047794:123616-124215 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT147810 NZ_CP063303:2992228-2992321 [Yersinia pestis]
TAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGTA
TTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380DXA2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References