147805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2728429..2728958 Replicon chromosome
Accession NZ_CP047793
Organism Staphylococcus aureus strain UP_764

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3S87_RS13325 Protein ID WP_000621176.1
Coordinates 2728596..2728958 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S87_RS13320 Protein ID WP_000948331.1
Coordinates 2728429..2728599 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S87_RS13290 2723465..2724025 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
E3S87_RS13295 2724234..2724713 + 480 WP_001287082.1 hypothetical protein -
E3S87_RS13300 2724706..2726283 + 1578 WP_001294646.1 PH domain-containing protein -
E3S87_RS13305 2726276..2726767 + 492 WP_001286801.1 PH domain-containing protein -
E3S87_RS13310 2726771..2727130 + 360 WP_000581197.1 holo-ACP synthase -
E3S87_RS13315 2727196..2728344 + 1149 WP_001281140.1 alanine racemase -
E3S87_RS13320 2728429..2728599 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S87_RS13325 2728596..2728958 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S87_RS13330 2729307..2730308 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S87_RS13335 2730427..2730753 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S87_RS13340 2730755..2731234 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S87_RS13345 2731209..2731979 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T147805 WP_000621176.1 NZ_CP047793:2728596-2728958 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T147805 NZ_CP063301:c4929043-4928786 [Klebsiella grimontii]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATGCATC
AGGCCGCGTCACTTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTATCGCATCAATACCACCGGGCTGAATAATGTCCGCGCA
CAGCTGGATAATCGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147805 WP_000948331.1 NZ_CP047793:2728429-2728599 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147805 NZ_CP063301:c4928775-4928224 [Klebsiella grimontii]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCAATGACATTCTCCATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTTGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGGGCTTATCCGTCACGGCATTGAGCA
GTTGAAAGCCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCATGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGCGCTCAAAGCCTGCTGGATGCTGCAGCCGCTTTCATCT
CAGCCGCTGGGACGAACGGGTCAAATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References