Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1201451..1201928 Replicon chromosome
Accession NZ_CP047793
Organism Staphylococcus aureus strain UP_764

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S87_RS05955 Protein ID WP_000052076.1
Coordinates 1201740..1201928 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S87_RS05950 Protein ID WP_001059690.1
Coordinates 1201451..1201711 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S87_RS05915 1196843..1197559 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3S87_RS05920 1197707..1198129 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S87_RS05925 1198528..1199022 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S87_RS05930 1199178..1199795 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3S87_RS05935 1199868..1200449 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S87_RS05940 1200674..1200910 + 237 WP_000368687.1 hypothetical protein -
E3S87_RS05945 1200907..1201110 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S87_RS05950 1201451..1201711 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S87_RS05955 1201740..1201928 + 189 WP_000052076.1 hypothetical protein Toxin
E3S87_RS05960 1202116..1202685 + 570 WP_001106663.1 hypothetical protein -
E3S87_RS05965 1202773..1203057 + 285 WP_001004401.1 hypothetical protein -
E3S87_RS05970 1203119..1203337 + 219 WP_000005879.1 hypothetical protein -
E3S87_RS05975 1203834..1204034 - 201 WP_001059082.1 cold-shock protein -
E3S87_RS05980 1204391..1205077 - 687 WP_001574556.1 thermonuclease family protein -
E3S87_RS05985 1205418..1205975 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147796 WP_000052076.1 NZ_CP047793:1201740-1201928 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147796 NZ_CP063291:c56671-56366 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147796 WP_001059690.1 NZ_CP047793:1201451-1201711 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147796 NZ_CP063291:c56891-56673 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References