Detailed information of TA system TA147778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1784705..1785219
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: E3S88_RS08920
• Protein ID: WP_124779883.1
• Coordinates: 1784705..1784914 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: E3S88_RS08925
• Protein ID: WP_000138928.1
• Coordinates: 1784926..1785219 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS08900	1780213..1781571	-	1359	WP_070974397.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
E3S88_RS08905	1781586..1782656	-	1071	WP_070958415.1	D-alanine--D-alanine ligase	-
E3S88_RS08910	1782974..1784176	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
E3S88_RS08915	1784440..1784577	-	138	WP_000828354.1	hypothetical protein	-
E3S88_RS08920	1784705..1784914	-	210	WP_124779883.1	heavy-metal-associated domain-containing protein	Toxin
E3S88_RS08925	1784926..1785219	-	294	WP_000138928.1	copper-sensing transcriptional repressor CsoR	Antitoxin
E3S88_RS08930	1785385..1786869	+	1485	WP_000571551.1	cardiolipin synthase	-
E3S88_RS08935	1786897..1787544	+	648	WP_001187616.1	HD domain-containing protein	-
E3S88_RS08945	1788584..1789456	-	873	WP_000725802.1	membrane protein insertase YidC	-
E3S88_RS08950	1789542..1790183	-	642	WP_124779879.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7855.82 Da
• Isoelectric Point: 4.1008

>T147778 WP_124779883.1 NZ_CP047792:c1784914-1784705 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVIVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T147778 NZ_CP063242:4663493-4663882 [Pectobacterium carotovorum]
ATGAACTGGGTTAGCGCACAAGAGGTGATCGCCTTTCATGACCGGATCTTGCAACGTTTGCCCGGCGTAGCGGGAATGCC
CGATCCAGGTCGAGCGGAAGCGATTATCTACCGGGTACAGAATCGTACGCATTATGAAGGGATAACAGACGTCTTCGAAC
TGGCCGCCACTTACTGGGTGGCAGTTGCGCGTGGCCATATTTTTAATGATGGCAATAAGCGTACCGCGTTCTTCGTCACG
ATGACGTTTCTATACCGTAACGGCGTGCTGGTTCGCGATCACGACAACACGTTGGAGAATTTGACGGTAGAGGCTGCAAC
AGGAGCAAAAAACGTTGACCAGTTAGCACAGCATCTACGAAATTTGGAAGATGAGATCAGTCCTACTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11184.82 Da
• Isoelectric Point: 6.2243

>AT147778 WP_000138928.1 NZ_CP047792:c1785219-1784926 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT147778 NZ_CP063242:4663275-4663496 [Pectobacterium carotovorum]
ATGCGAACCTACACCTCGACTCAAGCCAGAGCCAACATTTCAGAAGTATTAGATGCTGCAACTCACGGCGAGCCGGTCGA
AATTACTCGTCGAGATGGAAGCTCAGCGGTGGTAATCAGCAAAGCGGAATTCGAGGCATACCAGAATGCCAAATTGGACG
CAGAGTTTGATCTGATTATGCAGCGCCACGGCCACACAATCGAAGCGCTGACTGACCGATGA