Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1784705..1785219 Replicon chromosome
Accession NZ_CP047792
Organism Staphylococcus aureus strain UP_794

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag E3S88_RS08920 Protein ID WP_124779883.1
Coordinates 1784705..1784914 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag E3S88_RS08925 Protein ID WP_000138928.1
Coordinates 1784926..1785219 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S88_RS08900 1780213..1781571 - 1359 WP_070974397.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3S88_RS08905 1781586..1782656 - 1071 WP_070958415.1 D-alanine--D-alanine ligase -
E3S88_RS08910 1782974..1784176 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S88_RS08915 1784440..1784577 - 138 WP_000828354.1 hypothetical protein -
E3S88_RS08920 1784705..1784914 - 210 WP_124779883.1 heavy-metal-associated domain-containing protein Toxin
E3S88_RS08925 1784926..1785219 - 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S88_RS08930 1785385..1786869 + 1485 WP_000571551.1 cardiolipin synthase -
E3S88_RS08935 1786897..1787544 + 648 WP_001187616.1 HD domain-containing protein -
E3S88_RS08945 1788584..1789456 - 873 WP_000725802.1 membrane protein insertase YidC -
E3S88_RS08950 1789542..1790183 - 642 WP_124779879.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7855.82 Da        Isoelectric Point: 4.1008

>T147778 WP_124779883.1 NZ_CP047792:c1784914-1784705 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVIVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147778 NZ_CP063242:4663493-4663882 [Pectobacterium carotovorum]
ATGAACTGGGTTAGCGCACAAGAGGTGATCGCCTTTCATGACCGGATCTTGCAACGTTTGCCCGGCGTAGCGGGAATGCC
CGATCCAGGTCGAGCGGAAGCGATTATCTACCGGGTACAGAATCGTACGCATTATGAAGGGATAACAGACGTCTTCGAAC
TGGCCGCCACTTACTGGGTGGCAGTTGCGCGTGGCCATATTTTTAATGATGGCAATAAGCGTACCGCGTTCTTCGTCACG
ATGACGTTTCTATACCGTAACGGCGTGCTGGTTCGCGATCACGACAACACGTTGGAGAATTTGACGGTAGAGGCTGCAAC
AGGAGCAAAAAACGTTGACCAGTTAGCACAGCATCTACGAAATTTGGAAGATGAGATCAGTCCTACTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT147778 WP_000138928.1 NZ_CP047792:c1785219-1784926 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147778 NZ_CP063242:4663275-4663496 [Pectobacterium carotovorum]
ATGCGAACCTACACCTCGACTCAAGCCAGAGCCAACATTTCAGAAGTATTAGATGCTGCAACTCACGGCGAGCCGGTCGA
AATTACTCGTCGAGATGGAAGCTCAGCGGTGGTAATCAGCAAAGCGGAATTCGAGGCATACCAGAATGCCAAATTGGACG
CAGAGTTTGATCTGATTATGCAGCGCCACGGCCACACAATCGAAGCGCTGACTGACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References