147773

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1559933..1560709 Replicon chromosome
Accession NZ_CP047792
Organism Staphylococcus aureus strain UP_794

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E3S88_RS07580 Protein ID WP_000031108.1
Coordinates 1559933..1560085 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag E3S88_RS07585 Protein ID WP_001251219.1
Coordinates 1560110..1560709 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S88_RS07565 1556066..1556887 + 822 WP_000669380.1 RluA family pseudouridine synthase -
E3S88_RS07570 1557353..1558738 - 1386 WP_124781612.1 class II fumarate hydratase -
E3S88_RS07575 1558934..1559329 - 396 WP_000901023.1 hypothetical protein -
E3S88_RS07580 1559933..1560085 - 153 WP_000031108.1 hypothetical protein Toxin
E3S88_RS07585 1560110..1560709 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
E3S88_RS07590 1560868..1561338 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E3S88_RS07595 1561343..1562470 - 1128 WP_185648672.1 tRNA epoxyqueuosine(34) reductase QueG -
E3S88_RS07600 1562621..1563343 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E3S88_RS07605 1563336..1564793 - 1458 WP_160194564.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T147773 WP_000031108.1 NZ_CP047792:c1560085-1559933 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T147773 NZ_CP063242:3780057-3780362 [Pectobacterium carotovorum]
ATGCAATTCATTGTTTATAAATACAAAAGATCCAGCCACTACAGGATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCCAAGAGGCGTATGGTCATTCCGCTTATCGAAGCACATCATCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTCAGA
TTCGCATCGATGGCGAGAACTATCGGCTGATGACCACTGAGCTATCGAGCGTTCCCGTTGAGGTTATTGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT147773 WP_001251219.1 NZ_CP047792:c1560709-1560110 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT147773 NZ_CP063242:3779836-3780054 [Pectobacterium carotovorum]
ATGAAACACCGTGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATAAAAGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCGAGATTCATAGCACAGCATGGCTCCTTTGCAGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References