Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 510241..510718 Replicon chromosome
Accession NZ_CP047792
Organism Staphylococcus aureus strain UP_794

Toxin (Protein)


Gene name TsaT Uniprot ID -
Locus tag E3S88_RS02515 Protein ID WP_124781542.1
Coordinates 510241..510429 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID -
Locus tag E3S88_RS02520 Protein ID WP_031824382.1
Coordinates 510458..510718 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S88_RS02485 506281..506751 + 471 WP_124781540.1 hypothetical protein -
E3S88_RS02490 507092..507778 + 687 WP_001641381.1 thermonuclease family protein -
E3S88_RS02495 508135..508335 + 201 WP_001059082.1 cold-shock protein -
E3S88_RS02500 508832..509050 - 219 WP_000005884.1 hypothetical protein -
E3S88_RS02505 509111..509395 - 285 WP_124781541.1 hypothetical protein -
E3S88_RS02510 509484..510053 - 570 WP_001106648.1 hypothetical protein -
E3S88_RS02515 510241..510429 - 189 WP_124781542.1 hypothetical protein Toxin
E3S88_RS02520 510458..510718 - 261 WP_031824382.1 hypothetical protein Antitoxin
E3S88_RS02525 511059..511262 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S88_RS02530 511259..511495 - 237 WP_000368687.1 hypothetical protein -
E3S88_RS02535 511720..512301 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S88_RS02540 512374..512991 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
E3S88_RS02545 513148..513642 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
E3S88_RS02550 514041..514463 - 423 WP_124781543.1 organic hydroperoxide resistance protein -
E3S88_RS02555 514611..515327 + 717 WP_124781544.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7114.76 Da        Isoelectric Point: 9.9971

>T147770 WP_124781542.1 NZ_CP047792:c510429-510241 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILALMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147770 NZ_CP063242:c2990985-2990671 [Pectobacterium carotovorum]
ATGCAATTCACTGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGGCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTCCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGCACTCAGGTAAAGGCGGCACTAGACTTCCTTATCGACGGGTTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9988.18 Da        Isoelectric Point: 4.3698

>AT147770 WP_031824382.1 NZ_CP047792:c510718-510458 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKYLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147770 NZ_CP063242:c2991224-2990988 [Pectobacterium carotovorum]
ATGACCGCGAAACCACGCAACACGCAGAGCGTGACCATAACGGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGGAGCGGG
CATCAATCTGAGTGCTACTCTGTCAACCGCATTGGATGCGGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAAA
ACAGGGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAGCAGGGTTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References