Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1915395..1915909 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3S89_RS09730 Protein ID WP_000581791.1
Coordinates 1915395..1915604 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3S89_RS09735 Protein ID WP_000138934.1
Coordinates 1915616..1915909 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS09710 1911284..1912354 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
E3S89_RS09715 1912672..1913874 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S89_RS09720 1914035..1914718 - 684 Protein_1872 transposase -
E3S89_RS09725 1915130..1915267 - 138 WP_000828354.1 hypothetical protein -
E3S89_RS09730 1915395..1915604 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3S89_RS09735 1915616..1915909 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S89_RS09740 1916075..1917559 + 1485 WP_000571560.1 cardiolipin synthase -
E3S89_RS09745 1917587..1918234 + 648 WP_001187612.1 HD domain-containing protein -
E3S89_RS09755 1918391..1918690 + 300 WP_001793952.1 hypothetical protein -
E3S89_RS09760 1918847..1919719 - 873 WP_000725802.1 membrane protein insertase YidC -
E3S89_RS09765 1919805..1920446 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147763 WP_000581791.1 NZ_CP047791:c1915604-1915395 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147763 NZ_CP063241:c1507577-1507158 [Pectobacterium brasiliense]
ATGACAGATATCTTGCTCAACAAAAGCAGCACCATACAAAGATGCCTACGCCGTATCCGTGAGGAATTCGATACTGAGGA
AGGGTTTCGTCAGAACTTCACCAAGCAAGATTCCGTCATACTCAACATACAACGCGCCTGCGAAGCCGCGATTGATATCG
CCAATTATCTTATCCGTATCAAGCAGCTAGGCATACCACAGAGTAGCCGCGATAGCTTTGCGCTTCTCGCTGCAAACCAG
ATTATTACTCTTGAACTCTCTGACAATTTGCAAAAAATGGTGGGATTAAGAAACATTGCCGTGCATGACTATCAGACACT
CAATCTAGATATTGTCATCCACGTCATTTCTCATCGTTTAAGCGACTTTGAGCATTTTATCAAACAAATAGCCCGATACA
GCGACAGCCAGCACCTCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147763 WP_000138934.1 NZ_CP047791:c1915909-1915616 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147763 NZ_CP063241:c1507957-1507574 [Pectobacterium brasiliense]
ATGTTCGATGAGATCGTTTTGACACTGAAAAAACAGATGCCCGACATCAAGATTATTTACCTCTTTGGTTCCCAGGCAAC
GGGCAATGCCAGAGCAGACAGCGATGTTGATATCGCAATCATGGCGACGAAAGCCCTGGATCCCGTTGAACGCTGGGAGC
TATCCCACCAGTTAGCAAAAACAGTAGGCCATGATGTCGATCTTATCGATTTATTGCAGGCCTCGACGGTATTAAAAATG
GAGATCGTACGTAACGGCAAGCTACTTTACGATGCGGAAGCAACGGCGGGAGAATTTGAAATGACAACACTTTCGATGTA
CCAGCATCTGCAAAAAGAGCGGGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References