Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 563951..564428 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S89_RS02830 Protein ID WP_000052076.1
Coordinates 563951..564139 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S89_RS02835 Protein ID WP_001059690.1
Coordinates 564168..564428 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS02800 559904..560461 + 558 WP_000824491.1 hypothetical protein -
E3S89_RS02805 560802..561488 + 687 WP_001574556.1 thermonuclease family protein -
E3S89_RS02810 561845..562045 + 201 WP_001059082.1 cold-shock protein -
E3S89_RS02815 562542..562760 - 219 WP_000005879.1 hypothetical protein -
E3S89_RS02820 562822..563106 - 285 WP_001004401.1 hypothetical protein -
E3S89_RS02825 563194..563763 - 570 WP_001106663.1 hypothetical protein -
E3S89_RS02830 563951..564139 - 189 WP_000052076.1 hypothetical protein Toxin
E3S89_RS02835 564168..564428 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3S89_RS02840 564769..564972 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S89_RS02845 564969..565205 - 237 WP_000368687.1 hypothetical protein -
E3S89_RS02850 565430..566011 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S89_RS02855 566084..566701 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3S89_RS02860 566857..567351 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S89_RS02865 567750..568172 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S89_RS02870 568320..569036 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147754 WP_000052076.1 NZ_CP047791:c564139-563951 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147754 NZ_CP063241:151074-151349 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAGCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGCGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147754 WP_001059690.1 NZ_CP047791:c564428-564168 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147754 NZ_CP063241:151346-151708 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTATGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTATCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACACTTAGCGAACACCTGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References