Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1169327..1169804 Replicon chromosome
Accession NZ_CP047790
Organism Staphylococcus aureus strain UP_830

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S90_RS05840 Protein ID WP_000052076.1
Coordinates 1169616..1169804 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S90_RS05835 Protein ID WP_001059690.1
Coordinates 1169327..1169587 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S90_RS05800 1164720..1165436 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
E3S90_RS05805 1165584..1166006 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S90_RS05810 1166405..1166899 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S90_RS05815 1167054..1167671 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3S90_RS05820 1167744..1168325 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S90_RS05825 1168550..1168786 + 237 WP_000368687.1 hypothetical protein -
E3S90_RS05830 1168783..1168986 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S90_RS05835 1169327..1169587 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S90_RS05840 1169616..1169804 + 189 WP_000052076.1 hypothetical protein Toxin
E3S90_RS05845 1169992..1170561 + 570 WP_001106654.1 hypothetical protein -
E3S90_RS05850 1170649..1170933 + 285 WP_001004395.1 hypothetical protein -
E3S90_RS05855 1170995..1171213 + 219 WP_000005886.1 hypothetical protein -
E3S90_RS05860 1171709..1171909 - 201 WP_001059082.1 cold-shock protein -
E3S90_RS05865 1172266..1172952 - 687 WP_001792695.1 thermonuclease family protein -
E3S90_RS05870 1173293..1173814 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147740 WP_000052076.1 NZ_CP047790:1169616-1169804 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147740 NZ_CP063236:c295352-295047 [Rhodococcus qingshengii]
GTGCGCCCGATCCACGATGCGCAGCTCGGCGCGGGCGTTTCTTCGGTGTTGGTTCTGACGAGAGAGTTGGTTCGGCCTCA
TCTGGGGACGGTTACTGTTGCGCCGATTCGTGCGGAGGGGCGGGGGTTGTCGACGGAGCTGAGTTTGGGTGAAGGCAACG
GCGTCGAGGACGGATCTGTTGTCGATTGTGATGGGTTGACGACGATCCAGGTGTCGGCTCTCGGTGTGAACCGGGGGTTT
CTGCTGCCGGCGCAGGAAGTGTTGTTGACAAGGGCATTGCGATCAGCGTTCGACCTCGAATCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147740 WP_001059690.1 NZ_CP047790:1169327-1169587 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147740 NZ_CP063236:c295568-295353 [Rhodococcus qingshengii]
ATGAGTACGCAGATCGCGGTACGGCTGCCCGAGGGCATTGTGGCGTTTCTCGACGGTGAGGTCAGCGGCGGGCGCGCGAA
AAGCCGTGCCCAAGTCGTGCTTCGAGCATTGGAGCGTGAGCAGCGTCGGCAGTTGGCGGTCCGTGACGTGGAGATCTTGT
CTGACGGCGCAGGCGGCGATGTGAATATCGCTGCCGCGCACGGGAAGAAGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References