Detailed information of TA system TA147737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 129088..129864
• Replicon: chromosome
• Accession: NZ_CP047790
• Organism: Staphylococcus aureus strain UP_830

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: E3S90_RS00805
• Protein ID: WP_000031108.1
• Coordinates: 129712..129864 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: E3S90_RS00800
• Protein ID: WP_001251229.1
• Coordinates: 129088..129687 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S90_RS00780	125005..126462	+	1458	WP_000649907.1	ABC transporter permease subunit	-
E3S90_RS00785	126455..127177	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S90_RS00790	127328..128455	+	1128	WP_029160281.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S90_RS00795	128460..128930	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S90_RS00800	129088..129687	+	600	WP_001251229.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S90_RS00805	129712..129864	+	153	WP_000031108.1	hypothetical protein	Toxin
E3S90_RS00810	130698..131093	+	396	WP_000901023.1	hypothetical protein	-
E3S90_RS00815	131289..132674	+	1386	WP_000116231.1	class II fumarate hydratase	-
E3S90_RS00820	133127..133948	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	126449..220366	93917

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T147737 WP_000031108.1 NZ_CP047790:129712-129864 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T147737 NZ_CP063233:4372722-4372973 [Pseudomonas fluorescens]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAACACATGACATTCACCTGGCCCGAGCTCGTCACGCTGCT
GCGTCGGCTTGGCTACACACAAATCGAGGGGGCGGGAAGCCGCGTCAAGTTCGACATCGGCGACCCCACGGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGTCGCCAGGTCATCGAACAATTGAGATCAGGAGAC
CTGATTCAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22329.45 Da
• Isoelectric Point: 5.1445

>AT147737 WP_001251229.1 NZ_CP047790:129088-129687 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147737 NZ_CP063233:4372970-4373329 [Pseudomonas fluorescens]
GTGAACAACCAACTGAAATACAACGGTTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAAAT
CCTCTTCATCAAGGCGCTGGTCAGCTATGAAGGGAAAACCGTCGCCGAGTTGGACGCGGCCTTCCGCGAGGCCGTGGATG
ACTATCTCGCGACCTGCCAGACCCTGGGGCAAACCCCGGAGAAGCCATGCAAAGGCTCGTTCAATGTGCGGGTCGGCCAT
GACCTGCACCTGGCCGCGGCCCTGGCGGCAACCCGTAAGAAAGTCACGCTCAACGACCTGACGCGCCAGGCGTTGAACGA
GTTCCTGCAACACCACGGCGCAGACCCGGCGATCGGTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6