Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2704856..2705370 Replicon chromosome
Accession NZ_CP047789
Organism Staphylococcus aureus strain UP_967

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S93_RS13505 Protein ID WP_000581792.1
Coordinates 2705161..2705370 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S93_RS13500 Protein ID WP_000138932.1
Coordinates 2704856..2705149 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S93_RS13470 2700119..2700760 + 642 WP_000483153.1 thiamine phosphate synthase -
E3S93_RS13475 2700846..2701718 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S93_RS13490 2702531..2703178 - 648 WP_001187629.1 HD domain-containing protein -
E3S93_RS13495 2703206..2704690 - 1485 WP_000571549.1 cardiolipin synthase -
E3S93_RS13500 2704856..2705149 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S93_RS13505 2705161..2705370 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S93_RS13510 2705498..2705635 + 138 WP_000828354.1 hypothetical protein -
E3S93_RS13515 2705899..2707101 - 1203 WP_001109935.1 rod shape-determining protein RodA -
E3S93_RS13520 2707419..2708489 + 1071 WP_000159633.1 D-alanine--D-alanine ligase -
E3S93_RS13525 2708504..2709862 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147732 WP_000581792.1 NZ_CP047789:2705161-2705370 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147732 NZ_CP063229:4766977-4767267 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGGAGGCAGTCGCAGCCGTCTGATCCCCGGCGCGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATGTTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCGCGGGTAACT
ATTACAAGCGGCTGTCCGGGCCGTTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGACGCCGCTGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147732 WP_000138932.1 NZ_CP047789:2704856-2705149 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147732 NZ_CP063229:4767283-4767606 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGGGAAGTGCTGCAGGAAGAGTATTTAACGCCGTTGGGCATCGG
TCAGGAGGAATTGGCAAAGGTTTTGGGCGTCACCCGCGCCACCGTCAACCGCCTATGCAACGGGCATCGGCGCATGAGCG
TTACCGAGGCCAACCTGTTTGCCGATCTGTTCGAAACGACCACCGACTTTTGGCTGAACCTGCAGGCGGCGCACGATCGC
TGGGAGGCCAGACAGGCCAATGCACAGCGCGTGCGGCTGCGGCCAATCAAAGAAATACTGGGGCGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References