Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1222504..1222981 Replicon chromosome
Accession NZ_CP047789
Organism Staphylococcus aureus strain UP_967

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag E3S93_RS06245 Protein ID WP_000052078.1
Coordinates 1222793..1222981 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S93_RS06240 Protein ID WP_001059690.1
Coordinates 1222504..1222764 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S93_RS06205 1217897..1218613 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
E3S93_RS06210 1218761..1219183 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S93_RS06215 1219582..1220076 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S93_RS06220 1220231..1220848 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3S93_RS06225 1220921..1221502 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
E3S93_RS06230 1221727..1221963 + 237 WP_000368687.1 hypothetical protein -
E3S93_RS06235 1221960..1222163 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S93_RS06240 1222504..1222764 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S93_RS06245 1222793..1222981 + 189 WP_000052078.1 hypothetical protein Toxin
E3S93_RS06250 1223169..1223738 + 570 WP_001106654.1 hypothetical protein -
E3S93_RS06255 1223826..1224110 + 285 WP_001004395.1 hypothetical protein -
E3S93_RS06260 1224172..1224390 + 219 WP_000005886.1 hypothetical protein -
E3S93_RS06265 1224886..1225086 - 201 WP_001059082.1 cold-shock protein -
E3S93_RS06270 1225443..1226129 - 687 WP_001548082.1 thermonuclease family protein -
E3S93_RS06275 1226470..1226940 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-65)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T147724 WP_000052078.1 NZ_CP047789:1222793-1222981 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147724 NZ_CP063229:c1540974-1540669 [Serratia marcescens]
ATGCCCGCGTTTCGCCTCACCCCGCAAGCCCAACAAGATCTGCTGGCTATTCGTCATTTTACCGTCGAGCACTGGGGCAA
AGCGCAATCTCGCCGCTATCTTGAGCAGTTGAGAGAGGTCATGCATCATCTGGCGGATATGCCGGAAGCGGGTAAGGCCC
ACTTTCACGATCTGGGCGAAGAGATACGCAGTTTTCCTTACGCCAGCCATAGGATCTACTACCGCAGCCGCCCTGCCGGC
ATCACCGTGCTTGCCATTCTGCATCAGGCGATGGTGCCCCACCGGCATCTGGAACAACGGCTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147724 WP_001059690.1 NZ_CP047789:1222504-1222764 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147724 NZ_CP063229:c1541236-1540976 [Serratia marcescens]
ATGTACGCACTCAGCGCGAACGAGGCCAAAACCCAATTCGGCGATTTGCTGCTCAAGGCGCAGCGTGAGCCGGTGCAAAT
CAATCGCAACGGCAAACCGGTCGCCGTCGTCATGTCGGTAGAAGACTACCAGGCGCTGGAAGATCTCAAATTACGCGCGC
TGCAGCAAAAAATCGCGCAGGCTACCGCCGAGGAAGACGCCGATAAGGCAGTAGACGGCGATGCCTTCTTCAACCGTCTG
CTCACCGACGAAACCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References