Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2736545..2737059 Replicon chromosome
Accession NZ_CP047788
Organism Staphylococcus aureus strain UP_1033

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3S95_RS13445 Protein ID WP_000581791.1
Coordinates 2736850..2737059 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3S95_RS13440 Protein ID WP_000138934.1
Coordinates 2736545..2736838 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S95_RS13410 2732008..2732649 + 642 WP_000483150.1 thiamine phosphate synthase -
E3S95_RS13415 2732735..2733607 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S95_RS13420 2733764..2734063 - 300 WP_001793952.1 hypothetical protein -
E3S95_RS13430 2734220..2734867 - 648 WP_001187612.1 HD domain-containing protein -
E3S95_RS13435 2734895..2736379 - 1485 WP_000571560.1 cardiolipin synthase -
E3S95_RS13440 2736545..2736838 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S95_RS13445 2736850..2737059 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3S95_RS13450 2737187..2737324 + 138 WP_000828354.1 hypothetical protein -
E3S95_RS13455 2737736..2738419 + 684 Protein_2612 transposase -
E3S95_RS13460 2738580..2739782 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S95_RS13465 2740100..2741170 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147715 WP_000581791.1 NZ_CP047788:2736850-2737059 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147715 NZ_CP063224:c2373040-2372555 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147715 WP_000138934.1 NZ_CP047788:2736545-2736838 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147715 NZ_CP063224:c2373294-2373028 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References