147707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1242748..1243225 Replicon chromosome
Accession NZ_CP047788
Organism Staphylococcus aureus strain UP_1033

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S95_RS06270 Protein ID WP_000052076.1
Coordinates 1243037..1243225 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S95_RS06265 Protein ID WP_001059690.1
Coordinates 1242748..1243008 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S95_RS06230 1238140..1238856 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3S95_RS06235 1239004..1239426 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S95_RS06240 1239825..1240319 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S95_RS06245 1240475..1241092 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3S95_RS06250 1241165..1241746 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S95_RS06255 1241971..1242207 + 237 WP_000368687.1 hypothetical protein -
E3S95_RS06260 1242204..1242407 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S95_RS06265 1242748..1243008 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S95_RS06270 1243037..1243225 + 189 WP_000052076.1 hypothetical protein Toxin
E3S95_RS06275 1243413..1243982 + 570 WP_001106663.1 hypothetical protein -
E3S95_RS06280 1244070..1244354 + 285 WP_001004401.1 hypothetical protein -
E3S95_RS06285 1244416..1244634 + 219 WP_000005879.1 hypothetical protein -
E3S95_RS06290 1245131..1245331 - 201 WP_001059082.1 cold-shock protein -
E3S95_RS06295 1245688..1246374 - 687 WP_001574556.1 thermonuclease family protein -
E3S95_RS06300 1246715..1247272 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147707 WP_000052076.1 NZ_CP047788:1243037-1243225 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147707 NZ_CP063216:46085-46396 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147707 WP_001059690.1 NZ_CP047788:1242748-1243008 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147707 NZ_CP063216:46393-46812 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References