Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2024678..2025192 Replicon chromosome
Accession NZ_CP047787
Organism Staphylococcus aureus strain UP_1108

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag E3S97_RS09810 Protein ID WP_000581795.1
Coordinates 2024678..2024887 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag E3S97_RS09815 Protein ID WP_000138930.1
Coordinates 2024899..2025192 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S97_RS09790 2020186..2021544 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3S97_RS09795 2021559..2022629 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
E3S97_RS09800 2022947..2024149 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S97_RS09805 2024413..2024550 - 138 WP_000828354.1 hypothetical protein -
E3S97_RS09810 2024678..2024887 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
E3S97_RS09815 2024899..2025192 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S97_RS09820 2025358..2026842 + 1485 WP_000571562.1 cardiolipin synthase -
E3S97_RS09825 2026870..2027517 + 648 WP_001187625.1 HD domain-containing protein -
E3S97_RS09830 2028067..2028939 - 873 WP_000725802.1 membrane protein insertase YidC -
E3S97_RS09835 2029025..2029666 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T147691 WP_000581795.1 NZ_CP047787:c2024887-2024678 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147691 NZ_CP063214:4115221-4115535 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT147691 WP_000138930.1 NZ_CP047787:c2025192-2024899 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147691 NZ_CP063214:4114985-4115218 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References