Detailed information of TA system TA147690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2004935..2005464
• Replicon: chromosome
• Accession: NZ_CP047787
• Organism: Staphylococcus aureus strain UP_1108

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: E3S97_RS09720
• Protein ID: WP_000621175.1
• Coordinates: 2004935..2005297 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: E3S97_RS09725
• Protein ID: WP_000948331.1
• Coordinates: 2005294..2005464 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S97_RS09700	2001914..2002684	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
E3S97_RS09705	2002659..2003138	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
E3S97_RS09710	2003140..2003466	-	327	WP_001052491.1	anti-sigma factor antagonist	-
E3S97_RS09715	2003585..2004586	-	1002	WP_042744356.1	PP2C family protein-serine/threonine phosphatase	-
E3S97_RS09720	2004935..2005297	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
E3S97_RS09725	2005294..2005464	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
E3S97_RS09730	2005549..2006697	-	1149	WP_001281140.1	alanine racemase	-
E3S97_RS09735	2006763..2007122	-	360	WP_000581199.1	holo-ACP synthase	-
E3S97_RS09740	2007126..2007617	-	492	WP_001205907.1	PH domain-containing protein	-
E3S97_RS09745	2007604..2009187	-	1584	WP_001294637.1	PH domain-containing protein	-
E3S97_RS09750	2009180..2009659	-	480	WP_001287077.1	hypothetical protein	-
E3S97_RS09755	2009867..2010427	-	561	WP_001092406.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T147690 WP_000621175.1 NZ_CP047787:c2005297-2004935 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T147690 NZ_CP063214:c3998789-3998448 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT147690 WP_000948331.1 NZ_CP047787:c2005464-2005294 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT147690 NZ_CP063214:3998784-3998860 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1