Detailed information of TA system TA147687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1838497..1839273
• Replicon: chromosome
• Accession: NZ_CP047787
• Organism: Staphylococcus aureus strain UP_1108

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3S97_RS08760
• Protein ID: WP_000031109.1
• Coordinates: 1838497..1838649 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S97_RS08765
• Protein ID: WP_001251224.1
• Coordinates: 1838674..1839273 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S97_RS08745	1834303..1835124	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
E3S97_RS08750	1835581..1836966	-	1386	WP_000116239.1	class II fumarate hydratase	-
E3S97_RS08755	1837162..1837557	-	396	WP_000901019.1	hypothetical protein	-
E3S97_RS08760	1838497..1838649	-	153	WP_000031109.1	hypothetical protein	Toxin
E3S97_RS08765	1838674..1839273	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S97_RS08770	1839432..1839902	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S97_RS08775	1839907..1841034	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S97_RS08780	1841184..1841906	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S97_RS08785	1841899..1843356	-	1458	WP_000649916.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T147687 WP_000031109.1 NZ_CP047787:c1838649-1838497 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T147687 NZ_CP063214:3689045-3689218 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147687 WP_001251224.1 NZ_CP047787:c1839273-1838674 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147687 NZ_CP063214:3688721-3689017 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: W8U4V4