Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 819644..820121 Replicon chromosome
Accession NZ_CP047787
Organism Staphylococcus aureus strain UP_1108

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S97_RS03860 Protein ID WP_000052076.1
Coordinates 819644..819832 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S97_RS03865 Protein ID WP_001059690.1
Coordinates 819861..820121 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S97_RS03830 815634..816155 + 522 WP_000824479.1 hypothetical protein -
E3S97_RS03835 816496..817182 + 687 WP_001622483.1 thermonuclease family protein -
E3S97_RS03840 817539..817739 + 201 WP_001059082.1 cold-shock protein -
E3S97_RS03845 818236..818454 - 219 WP_000005884.1 hypothetical protein -
E3S97_RS03850 818527..818799 - 273 WP_001004400.1 hypothetical protein -
E3S97_RS03855 818887..819456 - 570 WP_001106662.1 hypothetical protein -
E3S97_RS03860 819644..819832 - 189 WP_000052076.1 hypothetical protein Toxin
E3S97_RS03865 819861..820121 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3S97_RS03870 820462..820665 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S97_RS03875 820662..820898 - 237 WP_000368687.1 hypothetical protein -
E3S97_RS03880 821122..821703 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S97_RS03885 821776..822393 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S97_RS03890 822549..823043 - 495 WP_064131596.1 GNAT family N-acetyltransferase -
E3S97_RS03895 823442..823864 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S97_RS03900 824012..824728 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147686 WP_000052076.1 NZ_CP047787:c819832-819644 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147686 NZ_CP063214:3356698-3356970 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CATAAGGGTATTAAAGATGATCTGTCTCCCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147686 WP_001059690.1 NZ_CP047787:c820121-819861 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147686 NZ_CP063214:3357010-3357300 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References