Detailed information of TA system TA147685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2748632..2749164
• Replicon: chromosome
• Accession: NZ_CP047786
• Organism: Staphylococcus aureus strain UP_1150

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: E3S98_RS13485
• Protein ID: WP_103144651.1
• Coordinates: 2748844..2749164 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: E3S98_RS13480
• Protein ID: WP_001058492.1
• Coordinates: 2748632..2748841 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S98_RS13445	2743878..2744162	+	285	WP_000917289.1	co-chaperone GroES	-
E3S98_RS13450	2744238..2745854	+	1617	WP_000240642.1	chaperonin GroEL	-
E3S98_RS13455	2745923..2747095	-	1173	WP_000179346.1	site-specific integrase	-
E3S98_RS13460	2747109..2747783	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
E3S98_RS13465	2747956..2748174	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
E3S98_RS13470	2748179..2748496	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
E3S98_RS13475	2748493..2748639	+	147	WP_000708434.1	hypothetical protein	-
E3S98_RS13480	2748632..2748841	+	210	WP_001058492.1	hypothetical protein	Antitoxin
E3S98_RS13485	2748844..2749164	+	321	WP_103144651.1	DUF1474 family protein	Toxin
E3S98_RS13490	2749228..2750097	+	870	WP_053040303.1	primase alpha helix C-terminal domain-containing protein	-
E3S98_RS13495	2750114..2751583	+	1470	WP_053040304.1	virulence-associated E family protein	-
E3S98_RS13500	2751862..2752224	+	363	WP_001039165.1	hypothetical protein	-
E3S98_RS13505	2752226..2752489	+	264	WP_001804819.1	hypothetical protein	-
E3S98_RS13510	2752491..2753132	+	642	WP_123090293.1	pathogenicity island protein	-
E3S98_RS13515	2753670..2754011	+	342	WP_001190610.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12724.24 Da
• Isoelectric Point: 4.7419

>T147685 WP_103144651.1 NZ_CP047786:2748844-2749164 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKTSSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T147685 NZ_CP063214:2538197-2538661 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT147685 WP_001058492.1 NZ_CP047786:2748632-2748841 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT147685 NZ_CP063214:2537862-2538197 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IA75