Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2677177..2677691 Replicon chromosome
Accession NZ_CP047786
Organism Staphylococcus aureus strain UP_1150

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S98_RS13125 Protein ID WP_000581792.1
Coordinates 2677482..2677691 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S98_RS13120 Protein ID WP_000138932.1
Coordinates 2677177..2677470 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S98_RS13100 2672787..2673428 + 642 WP_000483153.1 thiamine phosphate synthase -
E3S98_RS13105 2673514..2674386 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S98_RS13110 2674852..2675499 - 648 WP_001187630.1 HD domain-containing protein -
E3S98_RS13115 2675527..2677011 - 1485 WP_000571549.1 cardiolipin synthase -
E3S98_RS13120 2677177..2677470 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S98_RS13125 2677482..2677691 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S98_RS13130 2677819..2677956 + 138 WP_000828354.1 hypothetical protein -
E3S98_RS13135 2678220..2679422 - 1203 WP_045173480.1 rod shape-determining protein RodA -
E3S98_RS13140 2679740..2680810 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S98_RS13145 2680825..2682183 + 1359 WP_006190765.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147683 WP_000581792.1 NZ_CP047786:2677482-2677691 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147683 NZ_CP063214:c2202426-2202019 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147683 WP_000138932.1 NZ_CP047786:2677177-2677470 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147683 NZ_CP063214:c2202673-2202407 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References