Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1192357..1192834 Replicon chromosome
Accession NZ_CP047786
Organism Staphylococcus aureus strain UP_1150

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S98_RS05945 Protein ID WP_000052076.1
Coordinates 1192646..1192834 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S98_RS05940 Protein ID WP_001059690.1
Coordinates 1192357..1192617 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S98_RS05905 1187750..1188466 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
E3S98_RS05910 1188614..1189036 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S98_RS05915 1189435..1189929 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S98_RS05920 1190084..1190701 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E3S98_RS05925 1190774..1191355 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S98_RS05930 1191580..1191816 + 237 WP_000368687.1 hypothetical protein -
E3S98_RS05935 1191813..1192016 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S98_RS05940 1192357..1192617 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S98_RS05945 1192646..1192834 + 189 WP_000052076.1 hypothetical protein Toxin
E3S98_RS05950 1193022..1193591 + 570 WP_001106652.1 hypothetical protein -
E3S98_RS05955 1193679..1193963 + 285 WP_001004394.1 hypothetical protein -
E3S98_RS05960 1194025..1194243 + 219 WP_000005884.1 hypothetical protein -
E3S98_RS05965 1194738..1194938 - 201 WP_001059082.1 cold-shock protein -
E3S98_RS05970 1195295..1195981 - 687 WP_001792695.1 thermonuclease family protein -
E3S98_RS05975 1196322..1196843 - 522 WP_042909090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(7-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147674 WP_000052076.1 NZ_CP047786:1192646-1192834 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147674 NZ_CP063213:2260874-2261134 [Trueperella sp. 19M2397]
GTGAGCTATCGCGTTGAACTAACAACAGCCGCTGCTCGCCAGATTAAGAAACTGCCTCACGAAGCACGCGGTCGCATTTT
GGACGCGCTAGAGAAATTGGCGGACGATCCTCGGCCCCGCGGCGCAAAGAAGCTTGTCGGCGAACAGAATGCATGGCGAA
TTCGCCTCGGAGATTACCGAATTATTTATGACATCTTTGACGACATACTGACTGCAACAATCGTTCGCGCTGGGCATCGT
CGCGAAATTTACCGCAGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147674 WP_001059690.1 NZ_CP047786:1192357-1192617 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147674 NZ_CP063213:2260614-2260877 [Trueperella sp. 19M2397]
ATGAACACGATCACCAGCGAGGTCTCGACTCGCGAACTACGCAGCCAGCTCTCAGACGTTCTTGGGCGGGCCATGTACGC
CGGCGAACGCATCGGCGTCACCCGTCACGGAAAGCTAGCAGCTGTCGTCGTGAGCGTCGCAGATCTTGAGGCGCTCGAGG
AATTCGAGATGGCTCAGGATGTAGCCGCCTACCGTGCCGCTCGCGCGGAAGACGATGGCGGACGGGTGAGCCTTGATGAA
CTACGACGCACATTGACACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References