Detailed information of TA system TA147665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1700793..1701930
• Replicon: chromosome
• Accession: NZ_CP047785
• Organism: Staphylococcus aureus strain UP_1186

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: E3S99_RS08575
• Protein ID: WP_075100294.1
• Coordinates: 1700793..1701656 (-)
• Length: 288 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: Q9AL01
• Locus tag: E3S99_RS08580
• Protein ID: WP_002331065.1
• Coordinates: 1701658..1701930 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S99_RS08545	1695816..1696214	-	399	WP_160199764.1	DUF4064 domain-containing protein	-
E3S99_RS08550	1696363..1696737	-	375	WP_000822169.1	DUF4467 domain-containing protein	-
E3S99_RS08555	1697358..1697846	-	489	WP_000142089.1	TIGR01741 family protein	-
E3S99_RS08560	1697857..1698357	-	501	WP_000142105.1	TIGR01741 family protein	-
E3S99_RS08565	1698423..1699097	+	675	WP_001105991.1	IS6-like element IS257 family transposase	-
E3S99_RS08570	1700034..1700351	-	318	WP_049287895.1	hypothetical protein	-
E3S99_RS08575	1700793..1701656	-	864	WP_075100294.1	zeta toxin family protein	Toxin
E3S99_RS08580	1701658..1701930	-	273	WP_002331065.1	antitoxin	Antitoxin
E3S99_RS08585	1701947..1702156	-	210	WP_000527318.1	peptide-binding protein	-
E3S99_RS08590	1702255..1703151	-	897	WP_002334978.1	ParA family protein	-
E3S99_RS08600	1703414..1703986	-	573	WP_201750773.1	HTH domain-containing protein	-
E3S99_RS08610	1704262..1705056	-	795	WP_001096887.1	aminoglycoside O-phosphotransferase APH(3')-IIIa	-
E3S99_RS08615	1705149..1705679	-	531	WP_000627289.1	streptothricin N-acetyltransferase Sat4	-
E3S99_RS08620	1705676..1706584	-	909	WP_160199765.1	aminoglycoside 6-adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1698423..1699097	674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 288 a.a.
• Molecular weight: 32611.17 Da
• Isoelectric Point: 6.6627

>T147665 WP_075100294.1 NZ_CP047785:c1701656-1700793 [Staphylococcus aureus]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKTPKLPGL

Nucleotide

• Length: 864 bp

>T147665 NZ_CP063200:173391-173669 [Vibrio sp. SCSIO 43132]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGCGAAAAGATCTTTGAGTTTCTCTATGACTTCAATCCTGATGCAGC
AGAGAAAACCGACAGCCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAGCAACCTCTTATGGGCGTGCAAAGAAACGGAA
TTCGTGGACGTTTACTCATTATTCCTGAGGTATCAATAATCGTACCGTACTGGGTTGAAGGCGAAGTTATCCGCATTCTG
CGTGTGCTCCACCAAAAACAAAAATTCCCTACAGATTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10733.17 Da
• Isoelectric Point: 4.4865

>AT147665 WP_002331065.1 NZ_CP047785:c1701930-1701658 [Staphylococcus aureus]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA

Nucleotide

• Length: 273 bp

>AT147665 NZ_CP063200:173110-173394 [Vibrio sp. SCSIO 43132]
ATGGACACTAGAATTCAGTTTCGTGTTGATGAGGAAACAAAACGCTTAGCTCAGCAAATGGCTGAAAGCCAGGGTCGTAC
ATTGAGTGATGCTTGCCGAGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACACTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGCTTGACTCAGGAAAATCGGTTTTCGTTGAACATGAATCAGCTAAATCTCGA
ATGGAAGAACGCAAAGCCAGAATCCGTAACCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A828ZL55