Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1180810..1181287 Replicon chromosome
Accession NZ_CP047785
Organism Staphylococcus aureus strain UP_1186

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S99_RS06005 Protein ID WP_000052076.1
Coordinates 1181099..1181287 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S99_RS06000 Protein ID WP_001059690.1
Coordinates 1180810..1181070 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S99_RS05965 1176203..1176919 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S99_RS05970 1177067..1177489 + 423 WP_160199739.1 organic hydroperoxide resistance protein -
E3S99_RS05975 1177888..1178382 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S99_RS05980 1178538..1179155 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S99_RS05985 1179228..1179809 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S99_RS05990 1180033..1180269 + 237 WP_000368687.1 hypothetical protein -
E3S99_RS05995 1180266..1180469 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S99_RS06000 1180810..1181070 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S99_RS06005 1181099..1181287 + 189 WP_000052076.1 hypothetical protein Toxin
E3S99_RS06010 1181475..1182044 + 570 WP_001106662.1 hypothetical protein -
E3S99_RS06015 1182132..1182404 + 273 WP_001004400.1 hypothetical protein -
E3S99_RS06020 1182477..1182695 + 219 WP_000005884.1 hypothetical protein -
E3S99_RS06025 1183192..1183392 - 201 WP_001059082.1 cold-shock protein -
E3S99_RS06030 1183749..1184435 - 687 WP_001622483.1 thermonuclease family protein -
E3S99_RS06035 1184776..1185297 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147664 WP_000052076.1 NZ_CP047785:1181099-1181287 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147664 NZ_CP063198:c2038793-2038446 [Streptococcus agalactiae CJB111]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147664 WP_001059690.1 NZ_CP047785:1180810-1181070 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147664 NZ_CP063198:c2039070-2038783 [Streptococcus agalactiae CJB111]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References